Mitochondrial Etiology of Neuropsychiatric Disorders

Mitochondrial Dysfunction in Neuropsychiatric Disorders

Mitochondrial disorders were first described in 1962 (Luft, Ikkos, Palmieri, Ernster, & Afzelius, 1962), and were initially thought to be uniformly progressive and fatal with onset in infancy or early childhood, typically associated with severe neurological manifestations, including strokelike episodes, seizures, neuronal degeneration, organ failure and dementia. More recently, clinical observa...

Gut Microbiota and Neuropsychiatric Disorders

nArgBP2 as a hub molecule in the etiology of various neuropsychiatric disorders

Recent studies have strongly implicated postsynaptic scaffolding proteins such as SAPAP3 or Shank3 in the pathogenesis of various mood disorders, including autism spectrum disorder, bipolar disorder (BD), and obsessive-compulsive disorders. Neural Abelson-related gene-binding protein 2 (nArgBP2) was originally identified as a protein that interacts with SAPAP3 and Shank3. Recent study shows tha...

Bilingualism and neuropsychiatric disorders

A range of psychotic manifestations (including auditory hallucinations, delusions, conceptual disorganization, anxiety, and depression) have been reported to occur in either one or all of a patient’s languages. The reasons why one of the patient’s languages may be more affected than others is investigated. Whether a particular language should be used in psychotherapy, and if so, which one, is a...

Reelin and Neuropsychiatric Disorders

Proper neuronal migration and laminar formation during corticogenesis is essential for normal brain function. Disruption of these developmental processes is thought to be involved in the pathogenesis of some neuropsychiatric conditions. Especially, Reelin, a glycoprotein mainly secreted by the Cajal-Retzius cells and a subpopulation of GABAergic interneurons, has been shown to play a critical r...